[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism
Identifieur interne : 004589 ( Main/Exploration ); précédent : 004588; suivant : 004590[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism
Auteurs : Pramod K. Pal [Canada] ; Joanne Leung [États-Unis] ; Katya Hedrich [Allemagne] ; Ali Samii [Canada] ; Abraham Lieberman [États-Unis] ; Paul A. Nausieda [États-Unis] ; Donald B. Calne [Canada] ; Xandra O. Breakefield [États-Unis] ; Christine Klein [Allemagne] ; A. Jon Stoessl [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2002.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of 18F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.
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Pal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Joanne" sort="Leung, Joanne" uniqKey="Leung J" first="Joanne" last="Leung">Joanne Leung</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hedrich, Katya" sort="Hedrich, Katya" uniqKey="Hedrich K" first="Katya" last="Hedrich">Katya Hedrich</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departments of Neurology and Human Genetics, Medical University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Lieberman, Abraham" sort="Lieberman, Abraham" uniqKey="Lieberman A" first="Abraham" last="Lieberman">Abraham Lieberman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>National Parkinson Foundation, Inc.</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nausieda, Paul A" sort="Nausieda, Paul A" uniqKey="Nausieda P" first="Paul A." last="Nausieda">Paul A. 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Breakefield</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departments of Neurology and Human Genetics, Medical University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0456873</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0456873 INIST</idno><idno type="RBID">Pascal:02-0456873</idno><idno type="wicri:Area/PascalFrancis/Corpus">002684</idno><idno type="wicri:Area/PascalFrancis/Curation">000637</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002557</idno><idno type="wicri:Area/Main/Merge">006596</idno><idno type="wicri:Area/Main/Curation">004589</idno><idno type="wicri:Area/Main/Exploration">004589</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">[<sup>18</sup>F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism</title><author><name sortKey="Pal, Pramod K" sort="Pal, Pramod K" uniqKey="Pal P" first="Pramod K." last="Pal">Pramod K. Pal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Joanne" sort="Leung, Joanne" uniqKey="Leung J" first="Joanne" last="Leung">Joanne Leung</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hedrich, Katya" sort="Hedrich, Katya" uniqKey="Hedrich K" first="Katya" last="Hedrich">Katya Hedrich</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departments of Neurology and Human Genetics, Medical University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Lieberman, Abraham" sort="Lieberman, Abraham" uniqKey="Lieberman A" first="Abraham" last="Lieberman">Abraham Lieberman</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>National Parkinson Foundation, Inc.</s1><s2>Miami, Florida</s2><s3>USA</s3><sZ>5 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nausieda, Paul A" sort="Nausieda, Paul A" uniqKey="Nausieda P" first="Paul A." last="Nausieda">Paul A. Nausieda</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>NPF Centre of Excellence, St. Joseph's Hospital</s1><s2>Milwaukee, Wisonsin</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Milwaukee, Wisonsin</wicri:noRegion></affiliation></author><author><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Breakefield, Xandra O" sort="Breakefield, Xandra O" uniqKey="Breakefield X" first="Xandra O." last="Breakefield">Xandra O. Breakefield</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology Molecular Neurogenetics Unit, Massachusetts General Hospital and Harvard Medical School</s1><s2>Boston, Massachusetts</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Departments of Neurology and Human Genetics, Medical University of Lübeck</s1><s2>Lübeck</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Lübeck</wicri:noRegion><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Lübeck</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Basal ganglion</term><term>Case study</term><term>Diagnosis</term><term>Early phase</term><term>Fluorodopa(18F)</term><term>Genetic determinism</term><term>Juvenile character</term><term>Male</term><term>Parkinsonism</term><term>Positron emission tomography</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinsonisme</term><term>Caractère juvénile</term><term>Phase initiale</term><term>Tomographie émission positon</term><term>Fluorodopa(18F)</term><term>Noyau gris central</term><term>Etude cas</term><term>Déterminisme génétique</term><term>Diagnostic</term><term>Adolescent</term><term>Mâle</term><term>Parkin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of <sup>18</sup>F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>États-Unis</li></country><region><li>Floride</li><li>Massachusetts</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Pal, Pramod K" sort="Pal, Pramod K" uniqKey="Pal P" first="Pramod K." last="Pal">Pramod K. Pal</name></noRegion><name sortKey="Calne, Donald B" sort="Calne, Donald B" uniqKey="Calne D" first="Donald B." last="Calne">Donald B. Calne</name><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Leung, Joanne" sort="Leung, Joanne" uniqKey="Leung J" first="Joanne" last="Leung">Joanne Leung</name></region><name sortKey="Breakefield, Xandra O" sort="Breakefield, Xandra O" uniqKey="Breakefield X" first="Xandra O." last="Breakefield">Xandra O. Breakefield</name><name sortKey="Lieberman, Abraham" sort="Lieberman, Abraham" uniqKey="Lieberman A" first="Abraham" last="Lieberman">Abraham Lieberman</name><name sortKey="Nausieda, Paul A" sort="Nausieda, Paul A" uniqKey="Nausieda P" first="Paul A." last="Nausieda">Paul A. Nausieda</name></country><country name="Allemagne"><noRegion><name sortKey="Hedrich, Katya" sort="Hedrich, Katya" uniqKey="Hedrich K" first="Katya" last="Hedrich">Katya Hedrich</name></noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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